**TRONCO** is an open-source R package package for TRanslational ONCOlogy developed by the BIMIB Lab of Università degli Studi di Milano Bicocca and by the Mishra's Lab of New York University. It implements up-to-date statistical algorithms to estimate Cancer Progression Models from a list of genomic lesions - e.g., somatic mutations, copy number variations or persistent epigenetic states - in a population of independent tumors, or in a single patient.

The up-to-date TRONCO (TRanslational ONCOlogy) webpage is available at **troncopackage.org**.