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Alternative Splicing in Animals and Plants

A key mechanism for expanding transcriptome and proteome complexity

October 3, 2008

Università di Milano-Bicocca, Dipartimento di Informatica Sistemistica e Comunicazione



  • A map of the points of interest is available.

Key Dates

Submission of contributed talks: September 20 , 2008
Notification to authors: September 25, 2008
Workshop: October 3, 2008


The workshop will start at 9:30 in the morning and will end at 18:00.

The final program is available here (graphical version).

Theme and Scope

Alternative splicing (AS) is the major determinant for the expansion of the transcriptome and proteome in eukaryotic organisms. AS has recently emerged as a key mechanism to modulate gene expression in a tissue-specific manner and it is also involved in the onset and progression of serious pathologies.

The rapid growing of EST and transcript data produced by large-scale sequencing has encouraged the development of computational methods to assess the alternative splicing pattern of genes from the analysis of spliced transcript alignments to the genome. The most recent studies on alternative splice sites detection have revealed that this topic is a quite challenging computational problem, being far from a solution. The so called spliced alignment problem is now even complicated by the next generation sequencing technologies. On the other side, data on splice sites produced by computational methods are largely used to investigate the crucial role of AS.

Aim of this workshop is to bring together the knowledge of researchers from different areas, ranging from theory of algorithms, molecular biology, computational biology and plant and human genomics, that are involved in the thorough investigation of this key mechanism by both computational and experimental approaches.

Submission of contributed talks

Both theoretical and applied contributions are welcome. Authors should submit a one-page short abstract to the conference chair (Paola Bonizzoni, A post-proceeding volume will be published collecting abstracts of all contributed talks.

Invited Speakers

Rita Casadio, University of Bologna, Italy
When a protein is a protein - Emerging functional and structural features from protein sequence analysis to validate putative proteins predicted by "alternative splicing"

Eduardo Eyras, Universitat Pompeu Fabra, Spain
Evolution of splicing factors and signals in eukaryotes

Davide Gabellini, Università Vita-Salute San Raffaele, Italy
Alternative Splicing could explain the peculiar involvement of specific muscle groups in FSHD

Michael Sammeth, Genome Bioinformatics Lab, Center for Genomics Regulation, Spain, and
Gabriel Valiente, Technical University of Catalonia, Spain
Complete Alternative Splicing events

Scientific Committee

Paola Bonizzoni (Conference Chair)
Università di Milano-Bicocca - Dipartimento di Informatica Sistemistica e Comunicazione

Giancarlo Mauri
Università di Milano-Bicocca - Dipartimento di Informatica Sistemistica e Comunicazione

Graziano Pesole
Università di Bari - Dipartimento di Biochimica e Biologia Molecolare

Pietro Piffanelli
Parco Tecnologico Padano - Scientific Coordinator of the Genomics Platform

Alessandra Stella
Parco Tecnologico Padano - Scientific Coordinator of the Bioinformatics Platform

Local Organizers

Gianluca Della Vedova,
Riccardo Dondi,
Flavio Mignone,
Yuri Pirola,
Raffaella Rizzi,

Additional Material

The ASWorkshop poster is available here.

How To Reach Us

DISCo is located in north east side of Milan, U14 building of Milano-Bicocca Campus. A map showing the location of U14 can be found here.

A map of the points of interest near the location of the workshop is available.

By bus

BUS 727: the bus links Milan Central Railway Station to Cinisello Balsamo - Cusano. The nearest stop to U14 is Via Bignami - close to CTO (Centro Traumatologico Ortopedico) hospital. Once there, go along the street perpendicular to viale Sarca under the sign "BREDA" (there is also an indication of "Bicocca Village"). After approximately 200 meters you reach U14.

From Stazione Greco stop you can reach the shuttle bus Eco-Bus Bicocca. Eco-Bus is the internal shuttle of the Bicocca Campus.

By the Underground

LINEA 1 (MM1) - Red Line: get off at SESTO MARELLI. Then take Via Fiume until an overpass. Walk on the right side of the overpass until you find a pedestrian gate. Enter the gate and after 50 meters, you find U14 on the left side (after Hangar Bicocca).
LINEA 2 (MM2) - Green Line: Get off at GARIBALDI. From here there is the tram 11 which stops in viale Fulvio Testi- via Bignami.
LINEA 3 (MM3) - Yellow Line: get off at ZARA. From here take the bus 724 and get off at Viale Sarca - Chiese.

By car

From the Torino-Venezia highway, take the "Milano-Viale Zara" exit and head towards the city centre (centro). Pass the sign indicating the Town limit (Comune di Milano) and turn on your left at the traffic light. Then, at the next traffic light, turn your right and take Viale Sarca. After about 500 m approximately (pass two traffic lights), when you see the BREDA sign and an indication of "Bicocca Village", turn on your left. After 200m, you will find U14 on your right.

By train

Train Come out the Central Railways Station (Stazione Centrale), go to your right and you will see several bus/tram stops. Take the bus "Cinisello Balsamo-S. Eusebio" or "Cusano-via Sormani" (see tram and bus).

Trains also leave from Lambrate Station or Garibaldi Railway Station to Stazione Milano Greco Pirelli.

By plane

Landing at Milano Linate Airport: take bus n. 73 to Piazza S. Babila, then take MM1 (see subway above).
From Milano Malpensa Airport: take Malpensa Express to Milan (Cadorna Station). From here take the subway MM1 (see subway).
From Bergamo Orio: take the bus Ziani Viaggi to Lambrate. From here, either take the train to Milano Greco Pirelli or follow the underground instructions for the green line mentioned above.


There is no fee for attending the workshop, but you are kindly requested to register.

The current list of registered partecipants.


The Department is not located downtown, therefore there are only a few hotels nearby. The only hotel within walking distance is Albergo Starhotels. Several other hotels, which can be reached in less than 30 minutes by bus, can be found close to the main railway station (Stazione Centrale).